RO7300490

DB17535InvestigationalProtein Based Therapies

RO7300490 is an investigational Fibroblast Activation Protein-α (FAP) targeted CD40 agonist. RO7300490 is under investigation in clinical trial NCT04857138 (A Study to Evaluate Safety, Pharmacokinetics and Anti-tumor Activity of RO7300490,...

Mechanism: Pharmacologically active on Tumor necrosis factor receptor superfamily member 5 and Prolyl endopeptidase FAP
Curator reviewed
Also known as: RO 7300490 · RO-7300490
Code names: RG6189

Resolves to

Targets

P25942CD40Q12884FAP

What you can answer from here — as of July 08, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with RO7300490, and which of those have an active Phase 3 trial?

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