CHF-6333

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DB17815InvestigationalSmall molecule

CHF-6333: Overview.

Mechanism: Pharmacologically active on Neutrophil elastase
Curator reviewed
Formula / weight: C₂₈H₃₁F₃N₆O₆S · 636.65 g/mol (avg)
Also known as: (r)-2-(5-cyano-2-(6-(methoxycarbonyl)-7-methyl-3-oxo-8-(3-(trifluoromethyl)phenyl)-2,3,5,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrimidin-5-yl)phenyl)-n,n,n-trimethylethanaminium methanesulfonate · (r)-2-(5-cyano-2-(6-(methoxycarbonyl)-7-methyl-3-oxo-8-(3-(trifluoromethyl)phenyl)-2,3,5,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrimidin-5-yl)phenyl)-n,n,n-trimethylethanaminium methanesulfonate dehydrate · Benzeneethanaminium, 5-cyano-n,n,n-trimethyl-2-((5r)-2,3,5,8-tetrahydro-6-(methoxycarbonyl)-7-methyl-3-oxo-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo(4,3-a)pyrimidin-5-yl)-, methanesulfonate (1:1) · Chf-6333 mesylate · Gplscd01
Code names: CHF-6333

Resolves to

Compound

UNIIQ0656F336YCAS1613621-54-7

Structure

InChIKeyPTLGCXRUDBXISG-GNAFDRTKSA-NSMILESCS([O-])(=O)=O.COC(=O)C1=C(C)N(C2=NNC(=O)N2[C@@H]1C1=CC=C(C=C1CC[N+](C)(C)C)C#N)C1=CC=CC(=C1)C(F)(F)F

Targets

P08246ELANE

What you can answer from here — as of July 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with CHF-6333, and which of those have an active Phase 3 trial?

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