Neutrophil elastase

BE0000394ProteinHumansELANE

Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes (PubMed:15140022). It is acted on by 24 drugs in DrugBank.

Gene name
ELANE
UniProtKB entry
P08246Swiss-Prot
Cellular location
Cytoplasmic vesicle, phagosome
Residues / weight
267 residues · 28,518 Da
Also known as
3.4.21.37 · Bone marrow serine protease · ELA2 · Elastase-2 · HLE

Resolves to

Protein
UniProtP08246UniProt nameELNE_HUMAN
Gene
HGNCHGNC:3309NCBI Gene1991GenBank296665GeneCardsELANE
Pharmacology
IUPHAR/GtoPdb2358KEGGhsa:1991
Structure
PDB1B0FPDB1H1BPDB1HNE
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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81+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neutrophil elastase, how selective are they, and which programs against it are still in active trials?

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