Rentosertib

DB18083InvestigationalSmall molecule

Rentosertib: Overview.

Mechanism: Pharmacologically active on TRAF2 and NCK-interacting protein kinase
Curator reviewed
Formula / weight: C₂₇H₃₀FN₇O · 487.583 g/mol (avg)
Also known as: 5’-(4-fluorophenyl)-3’-isopropyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-1H,3’H-[2,4’-biimidazole]-4-carboxamide
Code names: INS-018_055 · ISM001-055

Resolves to

Compound

Structure

InChIKeyZVDNXHUSIKGTSF-UHFFFAOYSA-NSMILESCC(C)N1C=NC(=C1C1=NC=C(N1)C(=O)NC1=CC=C(C=C1)N1CCN(C)CC1)C1=CC=C(F)C=C1

Targets

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rentosertib, and which of those have an active Phase 3 trial?

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