TRAF2 and NCK-interacting protein kinase

BE0009399ProteinHumansTNIK

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. It is acted on by 2 drugs in DrugBank.

Gene name
TNIK
UniProtKB entry
Q9UKE5Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,360 residues · 154,942 Da
Also known as
2.7.11.1 · KIAA0551

Resolves to

Protein
UniProtQ9UKE5UniProt nameTNIK_HUMAN
Gene
HGNCHGNC:30765NCBI Gene23043GeneCardsTNIK
Pharmacology
IUPHAR/GtoPdb2244KEGGhsa:23043
Structure
PDB2X7FPDB5AX9PDB5CWZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on TRAF2 and NCK-interacting protein kinase, how selective are they, and which programs against it are still in active trials?

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