Esuberaprost

DB18464InvestigationalSmall molecule

Esuberaprost (GP-1681), a drug intended for participants with pulmonary arterial hypertension, was under investigation in clinical trial NCT03657095 to evaluate its efficacy and safety.

Mechanism: Pharmacologically active on Prostacyclin receptor
Curator reviewed
Formula / weight: C₂₄H₃₀O₅ · 398.499 g/mol (avg)
Also known as: (+)-4-((1r,2r,3as,8bs)-2-hydroxy-1-((1e,3s,4s)-3-hydroxy-4-methyl-oct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1h-cyclopenta(b)(1)benzofuran-5-yl)butanoic acid · 1h-cyclopenta(b)benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-((1e,3s,4s)-3-hydroxy-4-methyl-1-octen-6-ynyl)-, (1r,2r,3as,8bs)- · Aps-314d free acid · Beraprost, (+)-
Code names: APS 314D · BPS-314D · GP-1681

Resolves to

Compound

UNII1JSN1I7582CAS94132-88-4ChEMBLCHEMBL3137314

Structure

InChIKeyCTPOHARTNNSRSR-NOQAJONNSA-NSMILES[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)[C@@H](C)CC#CC)[C@@]1([H])C1=CC=CC(CCCC(O)=O)=C1O2

Targets

P43119PTGIR

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Esuberaprost, and which of those have an active Phase 3 trial?

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