Rodatristat ethyl

DB18479InvestigationalSmall molecule

Rodatristat ethyl: Overview.

Mechanism: Pharmacologically active on Tryptophan 5-hydroxylase 1
Curator reviewed
Formula / weight: C₂₉H₃₁ClF₃N₅O₃ · 590.04 g/mol (avg)
Also known as: 2,8-diazaspiro(4.5)decane-3-carboxylic acid, 8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4-pyrimidinyl)-, ethyl ester, (3s)- · Ethyl (3s)-8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro(4.5)decane-3-carboxylate
Code names: KAR-5585

Resolves to

Compound

Structure

InChIKeyTZSZZENYCISATO-WIOPSUGQSA-NSMILESCCOC(=O)[C@@H]1CC2(CN1)CCN(CC2)C1=CC(O[C@H](C2=CC=C(Cl)C=C2C2=CC=CC=C2)C(F)(F)F)=NC(N)=N1

Targets

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rodatristat ethyl, and which of those have an active Phase 3 trial?

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