Tryptophan 5-hydroxylase 1

BE0000121ProteinHumansTPH1

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. It is acted on by 8 drugs in DrugBank.

Gene name
TPH1
UniProtKB entry
P17752Swiss-Prot
Residues / weight
444 residues · 50,985 Da
Also known as
1.14.16.4 · TPH · TPRH · TRPH · Tryptophan 5-monooxygenase 1

Resolves to

Protein
UniProtP17752UniProt nameTPH1_HUMAN
Gene
HGNCHGNC:12008NCBI Gene7166GenBank37955GeneCardsTPH1
Pharmacology
IUPHAR/GtoPdb1241KEGGhsa:7166
Structure
PDB1MLWPDB3HF6PDB3HF8
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptophan 5-hydroxylase 1, how selective are they, and which programs against it are still in active trials?

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