MALP-2

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DB18482ExperimentalSmall molecule

MALP-2: Overview.

Mechanism: Pharmacologically active on Toll-like receptor 2 and Toll-like receptor 6
Curator reviewed
Formula / weight: C₉₉H₁₆₇N₁₉O₃₀S · 2135.59 g/mol (avg)
Also known as: L-lysine, s-((2r)-2,3-bis((1-oxohexadecyl)oxy)propyl)-l-cysteinylglycyl-l-asparaginyl-l-asparaginyl-l-.alpha.-aspartyl-l-.alpha.-glutamyl-l-seryl-l-asparaginyl-l-isoleucyl-l-seryl-l-phenylalanyl-l-lysyl-l-.alpha.-glutamyl- · Macrophage-activating lipopeptide-2 · S-(2,3-bispalmitoyloxy-(2r)-propyl)-cysteinly-gnndesnisfkek · S-[2,3-bispalmitoyloxy-(2R)-propyl]-cysteinly-GNNDESNISFKEK
Code names: MALP-2

Resolves to

Compound

UNIIDZX5IUA94DCAS250718-44-6

Structure

InChIKeyDMWMUMWKGKGSNW-OPMCLZTFSA-NSMILES

CCCCCCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O)OC(=O)CCCCCCCCCCCCCCC

Targets

O60603TLR2Q9Y2C9TLR6

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with MALP-2, and which of those have an active Phase 3 trial?

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