KT-253

DB18487InvestigationalSmall molecule

KT-253 is a selective heterobifunctional small molecule degrader of mouse double minute 2 (MDM2).

Mechanism: Pharmacologically active on E3 ubiquitin-protein ligase Mdm2
Curator reviewed
Code names: KT-253

Resolves to

Targets

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with KT-253, and which of those have an active Phase 3 trial?

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