Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Ulixacaltamide
- DrugBank Accession Number
- DB18788
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Ulixacaltamide (DB18788)
- Weight
- Average: 383.89
Monoisotopic: 383.177583 - Chemical Formula
- C19H27ClFN3O2
- Synonyms
- Ulixacaltamide
- External IDs
- NP 169944
- NP-169944
- NP169944
- PRAX 944
- PRAX-944
- PRAX944
- Z 944
- Z-944
- Z944
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
Target Actions Organism AVoltage-dependent T-type calcium channel subunit alpha-1H modulatorHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- QT2PJH89C3
- CAS number
- 1199236-64-0
- InChI Key
- JOCLITFYIMJMNK-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25)
- IUPAC Name
- SMILES
- CC(C)(C)NC(=O)CN1CCC(CNC(=O)C2=CC(F)=CC(Cl)=C2)CC1
References
- General References
- Not Available
- External Links
- ChemSpider
- 29788896
- BindingDB
- 50192689
- ChEBI
- 194339
- ChEMBL
- CHEMBL3934636
- ZINC
- ZINC000068151606
- PDBe Ligand
- DZR
- PDB Entries
- 6kzp
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Modulator
- General Function
- Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216).
- Specific Function
- high voltage-gated calcium channel activity
- Gene Name
- CACNA1H
- Uniprot ID
- O95180
- Uniprot Name
- Voltage-dependent T-type calcium channel subunit alpha-1H
- Molecular Weight
- 259160.2 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Drug created at June 20, 2024 22:07 / Updated at August 27, 2024 19:17