Nemtabrutinib

DB18866InvestigationalSmall molecule

Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)).

Formula / weight: C₂₅H₂₃ClN₄O₄ · 478.93 g/mol (avg)
Also known as: (2-chloro-4-phenoxyphenyl)(4-(((3r,6s)-6-(hydroxymethyl)tetrahydro-2h-pyran-3-yl)amino)-7h-pyrrolo(2,3-d)pyrimidin-5-yl)methanone · 1,5-Anhydro-2-[[5-(2-chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3,4-trideoxy-D-erythro-hexitol · D-erythro-hexitol, 1,5-anhydro-2-((5-(2-chloro-4-phenoxybenzoyl)-7h-pyrrolo(2,3-d)pyrimidin-4-yl)amino)-2,3,4-trideoxy-
Code names: ARQ-531 · MK-1026

Resolves to

Compound

UNIIJTZ51LIXN4CAS2095393-15-8ChEMBLCHEMBL4756476

Structure

InChIKeyJSFCZQSJQXFJDS-QAPCUYQASA-NSMILESOC[C@@H]1CC[C@H](CO1)NC1=C2C(NC=C2C(=O)C2=CC=C(OC3=CC=CC=C3)C=C2Cl)=NC=N1

Targets

Q06187BTK

What you can answer from here — as of September 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

21Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Nemtabrutinib, and which of those have an active Phase 3 trial?

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