Tyrosine-protein kinase BTK

BE0001284ProteinHumansBTK

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). It is acted on by 31 drugs in DrugBank.

Gene name
BTK
UniProtKB entry
Q06187Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
659 residues · 76,281 Da
Also known as
2.7.10.2 · Agammaglobulinemia tyrosine kinase · AGMX1 · ATK · B-cell progenitor kinase

Resolves to

Protein
UniProtQ06187UniProt nameBTK_HUMAN
Gene
HGNCHGNC:1133NCBI Gene695GenBank312467GeneCardsBTK
Pharmacology
IUPHAR/GtoPdb1948KEGGhsa:695
Structure
PDB1AWWPDB1AWXPDB1B55
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
103Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
26GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
192+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Tyrosine-protein kinase BTK, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In