Saruparib
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Saruparib
- DrugBank Accession Number
- DB18982
- Background
Saruparib is under investigation in clinical trial NCT06380751 (Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in Hr-positive, Her2-negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or Palb2m Advanced Breast Cancer).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 406.49
Monoisotopic: 406.211724101 - Chemical Formula
- C22H26N6O2
- Synonyms
- 2-Pyridinecarboxamide, 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-
- 5-{4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3- yl)methyl]piperazin-1-yl}-N-methylpyridine-2- carboxamide
- Saruparib
- External IDs
- AZD 5305
- AZD-5305
- AZD5305
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 16MZ1V3RBT
- CAS number
- 2589531-76-8
- InChI Key
- WQAVGRAETZEADU-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H26N6O2/c1-3-16-11-19-20(26-21(16)29)10-15(12-24-19)14-27-6-8-28(9-7-27)17-4-5-18(25-13-17)22(30)23-2/h4-5,10-13H,3,6-9,14H2,1-2H3,(H,23,30)(H,26,29)
- IUPAC Name
- SMILES
- CCC1=CC2=NC=C(CN3CCN(CC3)C3=CC=C(N=C3)C(=O)NC)C=C2NC1=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 114641973
- ChEMBL
- CHEMBL5095220
Clinical Trials
- Clinical Trials
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Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Not Yet Recruiting Treatment Advanced Breast Cancer 1 somestatus stop reason just information to hide 3 Recruiting Treatment Metastatic Castration Sensitive Prostate Cancer (mCSPC) 1 somestatus stop reason just information to hide 2 Recruiting Treatment Bile Duct Cancer / Colorectal Cancer / Endometrial Cancer / Gastric Cancer / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Ovarian Cancer / Urothelial Cancer 1 somestatus stop reason just information to hide 1 Completed Treatment Advanced Malignant Solid Tumor 1 somestatus stop reason just information to hide 1 Recruiting Treatment Non-Small Cell Lung Cancer (NSCLC) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at June 27, 2024 21:20 / Updated at June 28, 2024 04:47