Poly [ADP-ribose] polymerase 1

BE0001717ProteinHumansPARP1

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). It is acted on by 42 drugs in DrugBank.

Gene name
PARP1
UniProtKB entry
P09874Swiss-Prot
Cellular location
Chromosome
Residues / weight
1,014 residues · 113,083 Da
Also known as
2.4.2.30 · ADP-ribosyltransferase diphtheria toxin-like 1 · ADPRT · ADPRT 1 · ARTD1

Resolves to

Protein
UniProtP09874UniProt namePARP1_HUMAN
Gene
HGNCHGNC:270NCBI Gene142GenBank1017423GeneCardsPARP1
Pharmacology
IUPHAR/GtoPdb2771KEGGhsa:142
Structure
PDB1UK0PDB1UK1PDB1WOK
Drugs

What you can answer from here — as of September 07, 2019

42DrugsApproved to experimental, with action, bond type and pharmacological action
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20Clinical trialsTrials of drugs acting on it, by phase and status
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75GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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177+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Poly [ADP-ribose] polymerase 1, how selective are they, and which programs against it are still in active trials?

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