CH-1504 L-isomer

DB19052InvestigationalSmall molecule

CH-1504 L-isomer is under investigation in clinical trial NCT01116141 (A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)).

Chemical structure of CH-1504 L-isomer
Formula / weight
C23H23N5O5 · 449.467 g/mol (avg)
Also known as
(2s)-2-((4-(2-(2,4-diaminoquinazolin-6-yl)ethyl)benzoyl)amino)-4-methylene-pentanedioic acid · 4-methylene-n-(4-(2-(2,4-diaminoquinazolin-6-yl)ethyl)benzoyl)-l-glutamic acid · L-glutamic acid, n-(4-(2-(2,4-diamino-6-quinazolinyl)ethyl)benzoyl)-4-methylene- · L-m-trex · L-mobiletrex
Code names
CH-4051 · L-CH 1504

Resolves to

Compound
UNII86T288K8BSCAS227016-66-2ChEMBLCHEMBL4802147
Structure
InChIKeyNAWXUBYGYWOOIX-SFHVURJKSA-NSMILESNC1=NC2=CC=C(CCC3=CC=C(C=C3)C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C2C(N)=N1
Targets
P00374DHFR

What you can answer from here — as of February 04, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1Clinical trialPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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