Dihydrofolate reductase

BE0000330ProteinHumansDHFR

Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner (PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595). It is acted on by 39 drugs in DrugBank.

Gene name
DHFR
UniProtKB entry
P00374Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
187 residues · 21,453 Da
Also known as
1.5.1.3

Resolves to

Protein
UniProtP00374UniProt nameDYR_HUMAN
Gene
HGNCHGNC:2861NCBI Gene1719GenBank182724GeneCardsDHFR
Pharmacology
IUPHAR/GtoPdb2603KEGGhsa:1719
Structure
PDB1BOZPDB1DHFPDB1DLR
Drugs

What you can answer from here — as of September 07, 2019

39DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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144+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydrofolate reductase, how selective are they, and which programs against it are still in active trials?

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