SPH-3127

DB19108InvestigationalSmall molecule

SPH-3127 is under investigation in clinical trial NCT05359068 (Study to Evaluate the Efficacy and Safety of SPH3127 in Patients With Mild-moderate Essential Hypertension).

Mechanism: Pharmacologically active on Renin
Curator reviewed
Formula / weight: C₂₂H₃₂N₆O₄ · 444.536 g/mol (avg)
Also known as: CARBAMIC ACID, N-(3-(3-((1R)-1-(CYCLOPROPYL((2R)-2-MORPHOLINYLCARBONYL)AMINO)ETHYL)-6-METHYL-1H-PYRAZOLO(3,4-B)PYRIDIN-1-YL)PROPYL)-, METHYL ESTER
Code names: SPH-3127

Resolves to

Compound

UNIIC2M78A9V6ZCAS1399849-02-5ChEMBLCHEMBL4110551

Structure

InChIKeyGRTDDIZIUSADLD-CRAIPNDOSA-NSMILESCOC(=O)NCCCN1N=C([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)C2=CC=C(C)N=C12

Targets

P00797REN

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

8Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with SPH-3127, and which of those have an active Phase 3 trial?

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