SPH-3127
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- SPH-3127
- DrugBank Accession Number
- DB19108
- Background
SPH-3127 is under investigation in clinical trial NCT05359068 (Study to Evaluate the Efficacy and Safety of SPH3127 in Patients With Mild-moderate Essential Hypertension).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 444.536
Monoisotopic: 444.248503534 - Chemical Formula
- C22H32N6O4
- Synonyms
- CARBAMIC ACID, N-(3-(3-((1R)-1-(CYCLOPROPYL((2R)-2-MORPHOLINYLCARBONYL)AMINO)ETHYL)-6-METHYL-1H-PYRAZOLO(3,4-B)PYRIDIN-1-YL)PROPYL)-, METHYL ESTER
- External IDs
- SPH 3127
- SPH-3127
- SPH3127
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- C2M78A9V6Z
- CAS number
- 1399849-02-5
- InChI Key
- GRTDDIZIUSADLD-CRAIPNDOSA-N
- InChI
- InChI=1S/C22H32N6O4/c1-14-5-8-17-19(26-27(20(17)25-14)11-4-9-24-22(30)31-3)15(2)28(16-6-7-16)21(29)18-13-23-10-12-32-18/h5,8,15-16,18,23H,4,6-7,9-13H2,1-3H3,(H,24,30)/t15-,18-/m1/s1
- IUPAC Name
- SMILES
- COC(=O)NCCCN1N=C([C@@H](C)N(C2CC2)C(=O)[C@H]2CNCCO2)C2=CC=C(C)N=C12
References
- General References
- Not Available
- External Links
- ChemSpider
- 76799450
- BindingDB
- 212579
- ChEMBL
- CHEMBL4110551
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Completed Treatment Hypertension, Essential Hypertension 1 somestatus stop reason just information to hide 2 Completed Treatment Hypertension, Essential Hypertension 1 somestatus stop reason just information to hide 2 Recruiting Treatment Mild to Moderate Ulcerative Colitis 1 somestatus stop reason just information to hide 2 Recruiting Treatment Ulcerative Colitis 1 somestatus stop reason just information to hide 1 Completed Treatment Hypertension 3 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at July 04, 2024 14:53 / Updated at July 05, 2024 04:35