Renin

BE0000270ProteinHumansREN

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium... It is acted on by 28 drugs in DrugBank.

Gene name
REN
UniProtKB entry
P00797Swiss-Prot
Cellular location
Secreted
Residues / weight
406 residues · 45,057 Da
Also known as
3.4.23.15 · Angiotensinogenase

Resolves to

Protein
UniProtP00797UniProt nameRENI_HUMAN
Gene
HGNCHGNC:9958NCBI Gene5972GenBank190994GeneCardsREN
Pharmacology
IUPHAR/GtoPdb2413KEGGhsa:5972
Structure
PDB1BBSPDB1BILPDB1BIM
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
12Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
88+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Renin, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In