Pixatimod

DB19166InvestigationalSmall molecule

Pixatimod is under investigation in clinical trial NCT05061017 (Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma...

Mechanism: Pharmacologically active on Heparanase and Toll-like receptor 9
Curator reviewed
Formula / weight: C₅₁H₈₈O₆₀S₁₃ · 2077.99 g/mol (avg)
Also known as: Pg-545 free acid

Resolves to

Compound

UNII66QR34C83NCAS1144617-49-1ChEMBLCHEMBL2078841

Structure

InChIKeyLNUFLCYMSVYYNW-ZPJMAFJPSA-NSMILES

[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)O[C@]1([H])O[C@H](COS(O)(=O)=O)[C@@H](O[C@@]2([H])O[C@H](COS(O)(=O)=O)[C@@H](O[C@@]3([H])O[C@H](COS(O)(=O)=O)[C@@H](O[C@@]4([H])O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]4OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]3OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O)[C@H](C)CCCC(C)C

Targets

Q9Y251HPSEQ9NR96TLR9

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pixatimod, and which of those have an active Phase 3 trial?

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