Heparanase

BE0001064ProteinHumansHPSE

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. It is acted on by 10 drugs in DrugBank.

Gene name
HPSE
UniProtKB entry
Q9Y251Swiss-Prot
Cellular location
Lysosome membrane
Residues / weight
543 residues · 61,148 Da
Also known as
3.2.1.166 · Endo-glucoronidase · HEP · Heparanase-1 · HPA

Resolves to

Protein
UniProtQ9Y251UniProt nameHPSE_HUMAN
Gene
HGNCHGNC:5164NCBI Gene10855GenBank5616197GeneCardsHPSE
Pharmacology
IUPHAR/GtoPdb2996KEGGhsa:10855
Structure
PDB5E8MPDB5E97PDB5E98
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Heparanase, how selective are they, and which programs against it are still in active trials?

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