Florquinitau (18F) is a fluorine-18 radioactive diagnostic tracer that binds aggregated tau and is used for brain PET imaging to identify tau neurofibrillary tangle pathology in adults with cognitive impairment being evaluated for Alzheimer's disease. It binds to aggregated tau protein, which in Alzheimer's disease forms the neurofibrillary tangles (NFTs) that are one of the two components required for a neuropathological diagnosis of the disease.
- Mechanism
- Curator reviewed · 3 references
Florquinitau F 18 binds to aggregated tau protein. In the brains of patients with Alzheimer's disease, tau aggregates combine to form NFTs, one of two components required for the neuropathological diagnosis of Alzheimer's disease. In in vitro binding studies using postmortem human brain homogenates containing tau NFTs, the dissociation constant (Kd) for florquinitau was 0.3 nM.
- Primary indication
- Florquinitau F 18 is indicated for positron emission tomography (PET) of the brain in adults with cognitive impairment who are being evaluated for Alzheimer’s disease to identify patients with tau neurofibrillary tangle (NFT) pathology.Curator reviewed · 1 structured indication
- Formula / weight
- C16H11FN4 · 277.293 g/mol (avg)
- Also known as
- Florquinitau F 18 · Florquinitau F-18 · Florquinitau F18
- Code names
- (18F) MK-6240 · MK-6240 · MK-6240 F-18
Resolves to
KAXAUWZJVWGFDO-SJPDSGJFSA-NSMILESNC1=C([18F])C=CC2=CN=C(C=C12)N1C=CC2=CC=NC=C12What you can answer from here — as of November 02, 2026
Which drugs share a target with Florquinitau (18F), and which of those have an active Phase 3 trial?
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