DB19215ApprovedInvestigationalSmall molecule
Florquinitau (18F) is a fluorine-18 radioactive diagnostic tracer that binds aggregated tau and is used for brain PET imaging to identify tau neurofibrillary tangle pathology in adults with cognitive impairment being evaluated for Alzheimer's disease. It binds to aggregated tau protein, which in Alzheimer's disease forms the neurofibrillary tangles (NFTs) that are one of the two components required for a neuropathological diagnosis of the disease.
- Mechanism
- Curator reviewed
Pharmacologically active on Microtubule-associated protein tau
- Primary indication
- Florquinitau F 18 is indicated for positron emission tomography (PET) of the brain in adults with cognitive impairment who are being evaluated for Alzheimer’s disease to identify patients with tau neurofibrillary tangle (NFT) pathology.Curator reviewed · 1 structured indication
- Formula / weight
- C16H11FN4 · 277.293 g/mol (avg)
- Also known as
- 5-isoquinolinamine, 6-(fluoro-18f)-3-(1h-pyrrolo(2,3-c)pyridin-1-yl)- · 6-fluoro-3-(1h-pyrrolo(2,3-c)pyridin-1-yl)isoquinolin-5-amine · Florquinitau F-18 · Florquinitau F18
- Code names
- (18F) MK-6240 · MK-6240 F-18
Resolves to
Structure
InChIKey
KAXAUWZJVWGFDO-SJPDSGJFSA-NSMILESNC1=C([18F])C=CC2=CN=C(C=C12)N1C=CC2=CC=NC=C12Targets
What you can answer from here — as of September 23, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Florquinitau (18F), and which of those have an active Phase 3 trial?
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