Microtubule-associated protein tau

BE0003474ProteinHumansMAPT

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). It is acted on by 21 drugs in DrugBank.

Gene name
MAPT
UniProtKB entry
P10636Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
758 residues · 78,927 Da
Also known as
MAPTL · MTBT1 · Neurofibrillary tangle protein · Paired helical filament-tau · PHF-tau

Resolves to

Protein
UniProtP10636UniProt nameTAU_HUMAN
Gene
HGNCHGNC:6893NCBI Gene4137GeneCardsMAPT
Pharmacology
KEGGhsa:4137
Structure
PDB10IJPDB10IKPDB1I8H
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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78GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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114+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Microtubule-associated protein tau, how selective are they, and which programs against it are still in active trials?

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