Atilotrelvir

DB19439InvestigationalSmall molecule

Atilotrelvir is under investigation in clinical trial NCT05041907 (Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)).

Mechanism: Pharmacologically active on Replicase polyprotein 1ab
Curator reviewed
Formula / weight: C₂₄H₃₂F₃N₅O₄ · 511.546 g/mol (avg)
Also known as: (1R,4S,6S)-N-{(1S)-1-ciano-2-[(3S)-2-oxopirrolidin-3-il]etil}-5-[(2S)-3,3-dimetil-2-(2,2,2-trifluoroacetamido)butanoil]-5-azaespiro[biciclo[2.2.1]heptano-2,1'-ciclopropano]-6-carboxamida · Spiro[2-azabicyclo[2.2.1]heptane-5,1′-cyclopropane]-3-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-2-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-, (1S,3S,4R)-

Resolves to

Compound

UNIIJVV7PSN6VLCAS2850365-55-6

Structure

InChIKeyGTRJFXDJASEGSW-KBCNZALWSA-NSMILES[H][C@@]12C[C@@]([H])([C@H](N1C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C#N)C1(CC1)C2

Targets

P0DTD1rep

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Atilotrelvir, and which of those have an active Phase 3 trial?

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