Replicase polyprotein 1ab

BE0010016ProteinSARS-CoV-2rep

Replicase polyprotein 1ab Multifunctional protein involved in the transcription and replication of viral RNAs. It is acted on by 32 drugs in DrugBank.

Gene name
rep
UniProtKB entry
P0DTD1Swiss-Prot
Cellular location
Host membrane
Residues / weight
7,096 residues · 794,051 Da
Also known as
ORF1ab polyprotein · pp1ab

Resolves to

Protein
UniProtP0DTD1UniProt nameR1AB_SARS2
Gene
NCBI Gene43740578
Structure
PDB5R7YPDB5R7ZPDB5R80
Drugs

What you can answer from here — as of September 03, 2020

32DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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16Pfam domainsDomain architecture mapped to Pfam families and clans
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74+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Replicase polyprotein 1ab, how selective are they, and which programs against it are still in active trials?

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