Tulmimetostat

DB19446InvestigationalSmall molecule

Tulmimetostat is under investigation in clinical trial NCT05467748 (EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer).

Mechanism: Pharmacologically active on Histone-lysine N-methyltransferase EZH2
Curator reviewed
Formula / weight: C₂₈H₃₆ClN₃O₅S · 562.12 g/mol (avg)
Also known as: (2R)-7-chloro-2-[trans-4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-{[6-methyl-4-(methylsulfanyl)-2-oxo-1,2-dihydropyridin-3-yl]methyl}-2H-1,3-benzodioxole-5-carboxamide · 1,3-Benzodioxole-5-carboxamide, 7-chloro-N-[[1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl]methyl]-2-[trans-4-(3-methoxy-1-azetidinyl)cyclohexyl]-2,4-dimethyl-, (2R)-
Code names: CPI-0209 · DZR123

Resolves to

Compound

UNIIOUQ4N85Z0BCAS2567686-02-4ChEMBLCHEMBL5095231ChEBI758808

Structure

InChIKeyCAAWBLRXQXMGHV-JAGNJQOISA-NSMILES[H][C@@]1(CC[C@@H](CC1)N1CC(C1)OC)[C@@]1(C)OC2=C(O1)C(C)=C(C=C2Cl)C(=O)NCC1=C(SC)C=C(C)NC1=O

Targets

Q15910EZH2

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Tulmimetostat, and which of those have an active Phase 3 trial?

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