Histone-lysine N-methyltransferase EZH2

BE0009562ProteinHumansEZH2

Catalytic subunit of the PRC2/EED-EZH2 complex, a Polycomb group (PcG) complex that methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:14532106, PubMed:15225548, PubMed:15385962, PubMed:16618801, PubMed:16936726,... It is acted on by 7 drugs in DrugBank.

Gene name
EZH2
UniProtKB entry
Q15910Swiss-Prot
Cellular location
Nucleus
Residues / weight
746 residues · 85,362 Da
Also known as
2.1.1.356 · Enhancer of zeste homolog 2 · ENX-1 · KMT6 · Lysine N-methyltransferase 6

Resolves to

Protein
UniProtQ15910UniProt nameEZH2_HUMAN
Gene
HGNCHGNC:3527NCBI Gene2146GeneCardsEZH2
Pharmacology
IUPHAR/GtoPdb2654KEGGhsa:2146
Structure
PDB4MI0PDB4MI5PDB5GSA
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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30GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone-lysine N-methyltransferase EZH2, how selective are they, and which programs against it are still in active trials?

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