Setileuton

DB19550InvestigationalSmall molecule

Setileuton is a small molecule drug. The usage of the INN stem '-leuton' in the name indicates that Setileuton is a 5-lipo-oxygenase inhibitor, anti-inflammatory. Setileuton is under investigation in clinical... Setileuton is under investigation in clinical trial NCT00404313 (The Effect of MK0633 in Patients With Chronic Asthma (0633-007)).

Mechanism: Pharmacologically active on Polyunsaturated fatty acid 5-lipoxygenase
Curator reviewed
Formula / weight: C₂₂H₁₇F₄N₃O₄ · 463.389 g/mol (avg)
Code names: MK-0633

Resolves to

Compound

UNII0U2750935PCAS910656-27-8ChEMBLCHEMBL2105653ChEBI751552PubChem11856170

Structure

InChIKeyMAOIDRRXRLYJNV-NRFANRHFSA-NSMILESCC[C@](O)(C1=NN=C(NCC2=CC=C3C(OC(=O)C=C3C3=CC=C(F)C=C3)=C2)O1)C(F)(F)F

Targets

P09917ALOX5

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Setileuton, and which of those have an active Phase 3 trial?

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