Polyunsaturated fatty acid 5-lipoxygenase

BE0000248ProteinHumansALOX5

Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:19022417, PubMed:21233389,... It is acted on by 66 drugs in DrugBank.

Gene name
ALOX5
UniProtKB entry
P09917Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
674 residues · 77,983 Da
Also known as
1.13.11.- · 5-lipoxygenase · 5-LO · Arachidonate 5-lipoxygenase · LOG5

Resolves to

Protein
UniProtP09917UniProt nameLOX5_HUMAN
Gene
HGNCHGNC:435NCBI Gene240GenBank187193GeneCardsALOX5
Pharmacology
IUPHAR/GtoPdb1385KEGGhsa:240
Structure
PDB3O8YPDB3V92PDB3V98
Drugs

What you can answer from here — as of September 03, 2024

66DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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34GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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186+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Polyunsaturated fatty acid 5-lipoxygenase, how selective are they, and which programs against it are still in active trials?

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