Upacicalcet

DB20023InvestigationalSmall molecule

Upacicalcet is a small molecule drug. The usage of the INN stem '-calcet/-calcet-' in the name indicates that Upacicalcet is a calcium-sensing receptor (CaSR) agonist. Upacicalcet is under investigation in... Upacicalcet is under investigation in clinical trial NCT05836220 (Parathyroid Hormone (PTH) Attenuation Trial in Hemodialysis-2).

Mechanism: Pharmacologically active on Extracellular calcium-sensing receptor
Curator reviewed
Formula / weight: C₁₁H₁₄ClN₃O₆S · 351.76 g/mol (avg)
Code names: AJT-240 · PLS-240 · SK-1403

Resolves to

Compound

UNII5C1222PBE2CAS1333218-50-0ChEMBLCHEMBL6068421ChEBI760333PubChem53374467

Structure

InChIKeyLHEYGVSDVBEYQF-QMMMGPOBSA-NSMILESCC1=C(Cl)C=C(C=C1NC(=O)NC[C@H](N)C(O)=O)S(O)(=O)=O

Targets

P41180CASR

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Upacicalcet, and which of those have an active Phase 3 trial?

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