Extracellular calcium-sensing receptor

BE0000509ProteinHumansCASR

G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:22789683, PubMed:23966241, PubMed:25104082, PubMed:25292184, PubMed:25766501, PubMed:26386835, PubMed:32817431, PubMed:33603117, PubMed:34194040,... It is acted on by 18 drugs in DrugBank.

Gene name
CASR
UniProtKB entry
P41180Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,078 residues · 120,673 Da
Also known as
CaR · CaSR · GPRC2A · hCasR · Parathyroid cell calcium-sensing receptor 1

Resolves to

Protein
UniProtP41180UniProt nameCASR_HUMAN
Gene
HGNCHGNC:1514NCBI Gene846GenBank599820GeneCardsCASR
Pharmacology
IUPHAR/GtoPdb54KEGGhsa:846
Structure
PDB5FBHPDB5FBKPDB5K5S
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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84+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Extracellular calcium-sensing receptor, how selective are they, and which programs against it are still in active trials?

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