Aftobetin

DB20425InvestigationalSmall molecule

Aftobetin is a small molecule drug. Aftobetin is under investigation in clinical trial NCT02928211 (Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations).... Aftobetin has a monoisotopic molecular weight of 452.23 Da.

Mechanism: Pharmacologically active on Amyloid-beta precursor protein and Beta amyloid plaque
Curator reviewed
Formula / weight: C₂₆H₃₂N₂O₅ · 452.551 g/mol (avg)
Code names: ANCA-11 · COMPOUND 11

Resolves to

Compound

UNII9GY611K4TCCAS1208971-05-4ChEMBLCHEMBL2364601

Structure

InChIKeyNRZNTGUFHSJBTD-HKOYGPOVSA-NSMILESCOCCOCCOCCOC(=O)C(=C\C1=CC2=CC=C(C=C2C=C1)N1CCCCC1)\C#N

Targets

P05067APP

What you can answer from here — as of September 16, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Aftobetin, and which of those have an active Phase 3 trial?

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