Avosentan

DB20899ExperimentalSmall molecule

Avosentan is a small molecule drug. The usage of the INN stem '-entan' in the name indicates that Avosentan is a endothelin receptor antagonist. Avosentan has a monoisotopic molecular weight...

Mechanism: Pharmacologically active on Endothelin-1 receptor
Curator reviewed
Formula / weight: C₂₃H₂₁N₅O₅S · 479.51 g/mol (avg)
Code names: RO 67-0565 · SPP-301

Resolves to

Compound

UNIIL94KSX715KCAS290815-26-8ChEMBLCHEMBL3989834ChEBI756349PubChem9912992

Structure

InChIKeyYBWLTKFZAOSWSM-UHFFFAOYSA-NSMILESCOC1=CC=CC=C1OC1=C(NS(=O)(=O)C2=NC=C(C)C=C2)N=C(N=C1OC)C1=CC=NC=C1

Targets

P25101EDNRA

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Avosentan, and which of those have an active Phase 3 trial?

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