Onametostat

DB21480InvestigationalSmall molecule

Onametostat is a small molecule drug. The usage of the INN stem '-metostat' in the name indicates that Onametostat is a histone N-methyltransferase inhibitor. Onametostat is under investigation in clinical... Onametostat is under investigation in clinical trial NCT06788509 (A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring).

Chemical structure of Onametostat
Formula / weight
C22H23BrN6O2 · 483.37 g/mol (avg)
Code names
JNJ-64619178

Resolves to

Compound
UNIIN8VKI8FPW0CAS2086772-26-9ChEMBLCHEMBL4249337
Structure
InChIKeyDBSMLQTUDJVICQ-CJODITQLSA-NSMILESNC1=C2C=CN([C@@H]3C[C@H](CCC4=CC5=NC(N)=C(Br)C=C5C=C4)[C@@H](O)[C@H]3O)C2=NC=N1
Targets
O14744PRMT5

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
2Clinical trialsPhase, status and sponsor resolved per trial
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which drugs share a target with Onametostat, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In