Protein arginine N-methyltransferase 5

BE0011121ProteinHumansPRMT5

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714,... It is acted on by 6 drugs in DrugBank.

Gene name
PRMT5
UniProtKB entry
O14744Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
637 residues · 72,683 Da
Also known as
2.1.1.320 · 72 kDa ICln-binding protein · Histone-arginine N-methyltransferase PRMT5 · HRMT1L5 · IBP72

Resolves to

Protein
UniProtO14744UniProt nameANM5_HUMAN
Gene
HGNCHGNC:10894NCBI Gene10419GeneCardsPRMT5
Pharmacology
IUPHAR/GtoPdb1256KEGGhsa:10419
Structure
PDB4GQBPDB4X60PDB4X61
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein arginine N-methyltransferase 5, and which indications are they being tested in?

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