Guretolimod

DB21487InvestigationalSmall molecule

Guretolimod is a small molecule drug. The usage of the INN stem '-tolimod' in the name indicates that Guretolimod is a toll-like receptor (TLR) agonist. Guretolimod is under investigation in... Guretolimod is under investigation in clinical trial NCT03416335 (A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile).

Mechanism: Pharmacologically active on Toll-like receptor 7
Curator reviewed
Formula / weight: C₂₄H₃₄F₃N₅O₄ · 513.562 g/mol (avg)
Code names: DSP-0509 · DSR-106509

Resolves to

Compound

UNII2UG29YVL56CAS1488364-57-3ChEMBLCHEMBL5314554ChEBI759254PubChem72548788

Structure

InChIKeyXWGKZKKNJOQUSG-SFHVURJKSA-NSMILESCCC[C@@H](CCO)NC1=C(CC2=C(OC)C=C(CN(CC(O)=O)CC(F)(F)F)C=C2)C(C)=NC(N)=N1

Targets

Q9NYK1TLR7

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Guretolimod, and which of those have an active Phase 3 trial?

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