Edaxeterkib

DB21490InvestigationalSmall molecule

Edaxeterkib is a small molecule drug. The usage of the INN stem '-terkib' in the name indicates that Edaxeterkib is a extracellular signal-regulated kinase (ERK) inhibitor. Edaxeterkib is under investigation... Edaxeterkib is under investigation in clinical trial NCT03051035 (First-in-Human Study of KO-947 in Non-Hematological Malignancies).

Chemical structure of Edaxeterkib
Formula / weight
C26H27N7O2 · 469.549 g/mol (avg)
Code names
KO 947

Resolves to

Compound
UNIID9F5G5D3GNCAS1695534-88-3ChEMBLCHEMBL5944209
Structure
InChIKeySQNCXVDXNAUREB-HXUWFJFHSA-NSMILESCOC1=NC=C(C=N1)C1=NNC2=CC3=C(CN([C@@H]4CCCN(CC5=CC=CC=C5)C4)C(=O)N3)C=C12
Targets
P29323EPHB2

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1Clinical trialPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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