Ephrin type-B receptor 2

BE0004549ProteinHumansEPHB2

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 5 drugs in DrugBank.

Gene name
EPHB2
UniProtKB entry
P29323Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,055 residues · 117,492 Da
Also known as
2.7.10.1 · Developmentally-regulated Eph-related tyrosine kinase · DRT · EK5 · ELK-related tyrosine kinase

Resolves to

Protein
UniProtP29323UniProt nameEPHB2_HUMAN
Gene
HGNCHGNC:3393NCBI Gene2048GeneCardsEPHB2
Pharmacology
IUPHAR/GtoPdb1831KEGGhsa:2048
Structure
PDB1B4FPDB1F0MPDB2QBX
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-B receptor 2, how selective are they, and which programs against it are still in active trials?

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