Zeteletinib

DB21491InvestigationalSmall molecule

Zeteletinib is a small molecule drug. The usage of the INN stem '-tinib' in the name indicates that Zeteletinib is a tyrosine kinase inhibitor. Zeteletinib is under investigation in clinical... Zeteletinib is under investigation in clinical trial NCT03780517 (Safety, Efficacy, and Tolerability of BOS172738 in Patients With Advanced Rearranged During Transfection (RET) Gene-Altered Tumors).

Chemical structure of Zeteletinib
Formula / weight
C25H23F3N4O4 · 500.478 g/mol (avg)
Code names
BOS-172738 · CAXM-1190B · DS-5010B

Resolves to

Compound
UNIIEP0P7SHM0UCAS2216753-97-6ChEMBLCHEMBL5095497
Structure
InChIKeyKOLQINCWMXQEOF-UHFFFAOYSA-NSMILESCOC1=C(OC)C=C2N=CC(=CC2=C1)C1=CC=C(CC(=O)NC2=CC(=NO2)C(C)(C)C(F)(F)F)C=N1
Targets
P07949RET

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1Clinical trialPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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