Proto-oncogene tyrosine-protein kinase receptor Ret

BE0002411ProteinHumansRET

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503,... It is acted on by 27 drugs in DrugBank.

Gene name
RET
UniProtKB entry
P07949Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,114 residues · 124,317 Da
Also known as
2.7.10.1 · Cadherin family member 12 · CDHF12 · CDHR16 · Proto-oncogene c-Ret

Resolves to

Protein
UniProtP07949UniProt nameRET_HUMAN
Gene
HGNCHGNC:9967NCBI Gene5979GeneCardsRET
Pharmacology
IUPHAR/GtoPdb2185KEGGhsa:5979
Structure
PDB2IVSPDB2IVTPDB2IVU
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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53Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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160+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proto-oncogene tyrosine-protein kinase receptor Ret, how selective are they, and which programs against it are still in active trials?

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