Zavacorilant

DB21509InvestigationalSmall molecule

Zavacorilant is a small molecule drug. The usage of the INN stem '-corilant' in the name indicates that Zavacorilant is a glucocorticoid receptor antagonist (non-steroidal). Zavacorilant is under investigation in... Zavacorilant is under investigation in clinical trial NCT04672512 (Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants).

Mechanism: Pharmacologically active on Glucocorticoid receptor
Curator reviewed
Formula / weight: C₂₅H₂₆FN₇O₃S₂ · 555.65 g/mol (avg)
Code names: CORT125329

Resolves to

Compound

UNII74XPH8W9F6CAS1781245-13-3

Structure

InChIKeyDUHWKWNCLIALLV-BVZFJXPGSA-NSMILES[H][C@@]12CCN(C[C@]1(CC1=C(C2)N(N=C1)C1=CC=C(F)C=C1)C(=O)C1=CSC=N1)S(=O)(=O)C1=NN(N=C1)C(C)C

Targets

P04150NR3C1

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Zavacorilant, and which of those have an active Phase 3 trial?

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