Glucocorticoid receptor

Details

Name
Glucocorticoid receptor
Kind
protein
Synonyms
  • GR
  • GRL
  • Nuclear receptor subfamily 3 group C member 1
Gene Name
NR3C1
UniProtKB Entry
P04150Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001584|Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Number of residues
777
Molecular Weight
85658.57
Theoretical pI
6.31
GO Classification
Functions
core promoter sequence-specific DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor activity / DNA-binding transcription factor activity, RNA polymerase II-specific / DNA-binding transcription repressor activity, RNA polymerase II-specific / estrogen response element binding / Hsp90 protein binding / identical protein binding / nuclear glucocorticoid receptor activity / nuclear receptor activity / protein kinase binding / RNA binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / sequence-specific double-stranded DNA binding / TBP-class protein binding
Processes
adrenal gland development / apoptotic process / astrocyte differentiation / cell division / cellular response to dexamethasone stimulus / cellular response to glucocorticoid stimulus / cellular response to transforming growth factor beta stimulus / chromatin organization / chromosome segregation / glucocorticoid metabolic process / intracellular steroid hormone receptor signaling pathway / mammary gland duct morphogenesis / maternal behavior / microglia differentiation / motor behavior / negative regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / neuroinflammatory response / positive regulation of miRNA transcription / positive regulation of neuron apoptotic process / positive regulation of transcription by RNA polymerase II / regulation of DNA-templated transcription / regulation of glucocorticoid biosynthetic process / regulation of gluconeogenesis / regulation of transcription by RNA polymerase II / synaptic transmission, glutamatergic
Components
centrosome / chromatin / cytosol / membrane / nuclear speck / protein-containing complex / spindle / synapse
General Function
Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity)
Specific Function
Core promoter sequence-specific dna binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0020486|Glucocorticoid receptor (NR3C1)
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA
Chromosome Location
5
Locus
5q31.3
External Identifiers
ResourceLink
UniProtKB IDP04150
UniProtKB Entry NameGCR_HUMAN
GenBank Protein ID31680
GenBank Gene IDX03225
GeneCard IDNR3C1
GenAtlas IDNR3C1
HGNC IDHGNC:7978
PDB ID(s)1M2Z, 1NHZ, 1P93, 3BQD, 3CLD, 3E7C, 3H52, 3K22, 3K23, 4CSJ, 4HN5, 4HN6, 4LSJ, 4MDD, 4P6W, 4P6X, 4UDC, 4UDD, 5CBX, 5CBY, 5CBZ, 5CC1, 5E69, 5E6A, 5E6B, 5E6C, 5E6D, 5EMC, 5EMP, 5EMQ, 5G3J, 5G5W, 5NFP, 5NFT, 5UC1, 5UC3, 5VA0, 5VA7, 6BQU, 6CFN, 6DXK, 6EL6, 6EL7, 6EL9, 6X6D, 6X6E, 6YMO, 6YO8, 6YOS, 7KRJ, 7KW7, 7PRV, 7PRW, 7PRX, 8A9G, 8FFV, 8FFW, 8VKZ
KEGG IDhsa:2908
IUPHAR/Guide To Pharmacology ID625
NCBI Gene ID2908
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
AmcinonideapprovedyestargetagonistDetails
Betamethasoneapproved, vet_approvedyestargetagonistDetails
Prednisoneapproved, vet_approvedyestargetagonistDetails
MometasoneexperimentalyestargetagonistDetails
Methylprednisoloneapproved, vet_approvedyestargetagonistDetails
BudesonideapprovedyestargetagonistDetails
Dexamethasoneapproved, investigational, vet_approvedyestargetagonistDetails
Hydrocortisoneapproved, vet_approvedyestargetagonistDetails
HydrocortamateapprovedyestargetagonistDetails
Loteprednol etabonateapprovedyestargetagonistDetails
Fluticasone propionateapprovedyestargetagonistDetails
Mifepristoneapproved, investigationalyestargetantagonistDetails
Hexane-1,6-DiolexperimentalyestargetinhibitorDetails
Flunisolideapproved, investigationalyestargetagonistDetails
Flumethasoneapproved, vet_approvedyestargetagonistDetails
ORG-34517investigationalyestargetantagonistDetails
Ciclesonideapproved, investigationalyestargetagonistDetails
Megestrol acetateapproved, investigational, vet_approvedunknowntargetagonistDetails
Prednicarbateapproved, investigationalyestargetagonistDetails
Prednisoloneapproved, vet_approvedyestargetagonistDetails
Fluoxymesteroneapproved, illicitunknowntargetantagonistDetails
Fluocinolone acetonideapproved, investigational, vet_approvedyestargetagonistDetails
FlurandrenolideapprovedyestargetagonistDetails
Beclomethasone dipropionateapproved, investigationalyestargetagonistDetails
Fludrocortisoneapproved, investigationalunknowntargetagonistDetails
Triamcinoloneapproved, vet_approvedyestargetagonistDetails
Clobetasol propionateapprovedyestargetagonistDetails
ClocortoloneapprovedyestargetagonistDetails
DesoximetasoneapprovedyestargetagonistDetails
RimexoloneapprovedyestargetagonistDetails
UlobetasolapprovedyestargetagonistDetails
MedrysoneapprovedyestargetagonistDetails
AlclometasoneapprovedyestargetagonistDetails
Desonideapproved, investigationalyestargetagonistDetails
DiflorasoneapprovedyestargetagonistDetails
Fluocinonideapproved, investigationalyestargetagonistDetails
ParamethasoneexperimentalyestargetagonistDetails
DifluprednateapprovedyestargetagonistDetails
Cortisone acetateapproved, investigationalyestargetagonistDetails
Fluorometholoneapproved, investigationalyestargetagonistDetails
UlipristalapprovedyestargetantagonistDetails
Fluticasone furoateapprovedyestargetagonistDetails
SpironolactoneapprovedunknowntargetantagonistDetails
ClobetasoneapprovedyestargetagonistDetails
Aldosteroneexperimental, investigationalunknowntargetDetails
CortivazolinvestigationalunknowntargetDetails
OnapristoneinvestigationalunknowntargetDetails
Progesteroneapproved, vet_approvedunknowntargetpartial agonistDetails
Tixocortolapproved, withdrawnyestargetbinderDetails
Difluocortoloneapproved, investigational, withdrawnyestargetbinderDetails
GestrinoneapprovedunknowntargetantagonistDetails
Mometasone furoateapproved, investigational, vet_approvedyestargetDetails
Hydrocortisone aceponateexperimental, vet_approvedyestargetDetails
Hydrocortisone acetateapproved, vet_approvedyestargetDetails
Hydrocortisone butyrateapproved, vet_approvedyestargetDetails
Hydrocortisone cypionateapproved, investigational, vet_approvedyestargetDetails
Hydrocortisone phosphateapproved, vet_approvedyestargetDetails
Hydrocortisone probutateapproved, vet_approvedyestargetDetails
Hydrocortisone valerateapproved, vet_approvedyestargetDetails
Segesterone acetateapproved, experimental, investigationalnotargetagonistDetails
Fluticasoneapproved, experimentalyestargetagonistDetails
Deflazacortapproved, investigationalunknowntargetagonistDetails
Levonorgestrelapproved, investigationalunknowntargetbinderDetails
DrospirenoneapprovedunknowntargetbinderDetails
Prednisolone acetateapproved, vet_approvedyestargetagonistDetails
NorethisteroneapprovedunknowntargetagonistDetails
Prednisolone phosphateapproved, vet_approvedunknowntargetagonistDetails
Betamethasone phosphateapproved, vet_approvedunknowntargetagonistDetails
Dexamethasone acetateapproved, investigational, vet_approvedyestargetagonistDetails
Vamoroloneapproved, investigationalyestargetagonistDetails
CorticosteroneexperimentalyestargetagonistDetails
AZD-5423investigationalyestargetagonistDetails
ExicorilantinvestigationalyestargetantagonistDetails
LonaprisaninvestigationalyestargetinhibitorDetails
Etiprednol dicloacetateinvestigationalyestargetmodulatorDetails
RelacorilantinvestigationalyestargetantagonistDetails
MapracoratinvestigationalyestargetagonistDetails
Meprednisoneapproved, investigationalyestargetmodulatorDetails