Vociprotafib

DB21559InvestigationalSmall molecule

Vociprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Vociprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. Vociprotafib is under... Vociprotafib is under investigation in clinical trial NCT05054725 (Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies).

Mechanism: Pharmacologically active on Tyrosine-protein phosphatase non-receptor type 11
Curator reviewed
Formula / weight: C₂₀H₂₇ClN₆O₂S · 450.99 g/mol (avg)
Code names: RMC-0694630 · RMC-4630 · SAR-442720

Resolves to

Compound

UNIIC4YBF9170LCAS2172652-48-9ChEMBLCHEMBL5314427ChEBI759138PubChem134182831

Structure

InChIKeyHISJAYUQVHMWTA-BLLLJJGKSA-NSMILESC[C@@H]1OCC2(CCN(CC2)C2=C(CO)N=C(SC3=C(Cl)C(N)=NC=C3)C(C)=N2)[C@@H]1N

Targets

Q06124PTPN11

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Vociprotafib, and which of those have an active Phase 3 trial?

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