Tyrosine-protein phosphatase non-receptor type 11

BE0001071ProteinHumansPTPN11

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573, PubMed:32184441). It is acted on by 7 drugs in DrugBank.

Gene name
PTPN11
UniProtKB entry
Q06124Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
593 residues · 68,010 Da
Also known as
3.1.3.48 · Protein-tyrosine phosphatase 1D · Protein-tyrosine phosphatase 2C · PTP-1D · PTP-2C

Resolves to

Protein
UniProtQ06124UniProt namePTN11_HUMAN
Gene
HGNCHGNC:9644NCBI Gene5781GenBank4519425GeneCardsPTPN11
Pharmacology
IUPHAR/GtoPdb3203KEGGhsa:5781
Structure
PDB2SHPPDB3B7OPDB3MOW
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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27GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein phosphatase non-receptor type 11, how selective are they, and which programs against it are still in active trials?

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