Opnurasib

DB21583InvestigationalSmall molecule

Opnurasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Opnurasib is a Ras protein inhibitor. Opnurasib is under investigation in clinical... Opnurasib is under investigation in clinical trial NCT05132075 (Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer).

Chemical structure of Opnurasib
Formula / weight
C29H28ClN7O · 526.04 g/mol (avg)
Code names
JDQ-443 · NVP-JDQ-443

Resolves to

Compound
UNIIQ3W0H3V1LQCAS2653994-08-0ChEMBLCHEMBL5077861
Structure
InChIKeyAZUYLZMQTIKGSC-UHFFFAOYSA-NSMILESCN1N=CC2=CC(=CC=C12)C1=NN(C2CC3(C2)CN(C3)C(=O)C=C)C(C)=C1C1=C2C=NNC2=CC(C)=C1Cl
Targets
P01116KRAS

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
8Clinical trialsPhase, status and sponsor resolved per trial
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which drugs share a target with Opnurasib, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In