GTPase KRas

BE0004071ProteinHumansKRAS

Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22711838, PubMed:23698361). It is acted on by 18 drugs in DrugBank.

Gene name
KRAS
UniProtKB entry
P01116Swiss-Prot
Cellular location
Cell membrane
Residues / weight
189 residues · 21,656 Da
Also known as
3.6.5.2 · c-K-ras · c-Ki-ras · K-Ras 2 · Ki-Ras

Resolves to

Protein
UniProtP01116UniProt nameRASK_HUMAN
Gene
HGNCHGNC:6407NCBI Gene3845GenBank186764GeneCardsKRAS
Pharmacology
IUPHAR/GtoPdb2824KEGGhsa:3845
Structure
PDB10JTPDB10NUPDB10NV
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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165Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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102+ReferencesStructured and connected to the statements they support
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Which approved drugs act on GTPase KRas, how selective are they, and which programs against it are still in active trials?

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