Sofnobrutinib

DB21626ExperimentalSmall molecule

Sofnobrutinib is a small molecule drug. The usage of the INN stem '-brutinib' in the name indicates that Sofnobrutinib is a agammaglobulinaemia tyrosine kinase (Bruton tyrosine kinase) inhibitor. Sofnobrutinib has... Sofnobrutinib has a monoisotopic molecular weight of 498.19 Da.

Mechanism: Pharmacologically active on Tyrosine-protein kinase BTK
Curator reviewed
Formula / weight: C₂₆H₂₃FN₈O₂ · 498.522 g/mol (avg)
Code names: AS-0871

Resolves to

Compound

UNIIPZP2D7F6L5CAS1646608-10-7ChEMBLCHEMBL4209441ChEBI756641PubChem87056204

Structure

InChIKeyRQYDQAPLARKISN-UHFFFAOYSA-NSMILESCN1C=C(NC2=NC(N)=NC(=N2)C2=CC=CC(N3C=CC4=CC(=CC(F)=C4C3=O)C3CC3)=C2CO)C=N1

Targets

Q06187BTK

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Sofnobrutinib, and which of those have an active Phase 3 trial?

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