Lotiglipron

DB21631InvestigationalSmall molecule

Lotiglipron is a small molecule drug. The usage of the INN stem '-glipron' in the name indicates that Lotiglipron is a glucagon-like peptide 1 receptor (GLPIR) agonist. Lotiglipron is under... Lotiglipron is under investigation in clinical trial NCT05579977 (Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity).

Chemical structure of Lotiglipron
Formula / weight
C31H31ClN4O5 · 575.06 g/mol (avg)
Code names
PF-07081532

Resolves to

Compound
UNIIYI10W1K93ACAS2401892-75-7ChEMBLCHEMBL5314631ChEBI759328PubChem146609022
Structure
InChIKeySVPYZAJTWFQTSM-UGDMGKLASA-NSMILESC[C@@]1(OC2=C(O1)C(=CC=C2)C1CCN(CC2=NC3=CC=C(C=C3N2C[C@@H]2CCO2)C(O)=O)CC1)C1=NC=C(Cl)C=C1
Targets
P43220GLP1R

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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11Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Lotiglipron, and which of those have an active Phase 3 trial?

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