Tegtociclib

DB21635InvestigationalSmall molecule

Tegtociclib is a small molecule drug. The usage of the INN stem '-ciclib' in the name indicates that Tegtociclib is a cyclin dependant kinase inhibitor. Tegtociclib is under investigation in... Tegtociclib is under investigation in clinical trial NCT05262400 (A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors).

Mechanism: Pharmacologically active on Cyclin-dependent kinase 2
Curator reviewed
Formula / weight: C₁₉H₂₈N₆O₄ · 404.471 g/mol (avg)
Also known as: Tagtociclib
Code names: PF-07104091

Resolves to

Compound

UNIIXBD0JF5EHJCAS2460249-19-6ChEMBLCHEMBL5201870ChEBI759071PubChem154616422

Structure

InChIKeyMTNBRBDFNSGQKB-GXTWGEPZSA-NSMILESCOCC1=NN(C)C(=C1)C(=O)NC1=NNC(=C1)[C@H]1CC[C@H](C1)OC(=O)NC(C)C

Targets

P24941CDK2

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Tegtociclib, and which of those have an active Phase 3 trial?

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