Cyclin-dependent kinase 2

BE0001072ProteinHumansCDK2

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). It is acted on by 161 drugs in DrugBank.

Gene name
CDK2
UniProtKB entry
P24941Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Residues / weight
298 residues · 33,929 Da
Also known as
2.7.11.22 · CDKN2 · Cell division protein kinase 2 · p33 protein kinase

Resolves to

Protein
UniProtP24941UniProt nameCDK2_HUMAN
Gene
HGNCHGNC:1771NCBI Gene1017GenBank3551191GeneCardsCDK2
Pharmacology
IUPHAR/GtoPdb1973KEGGhsa:1017
Structure
PDB1AQ1PDB1B38PDB1B39
Drugs

What you can answer from here — as of September 07, 2019

161DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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27GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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380+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 2, how selective are they, and which programs against it are still in active trials?

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